Most of Michigan's Lower Peninsula could see significant snow accumulation Wednesday into Thursday, according to the National Weather Service.

LANSING — Virtually all of lower Michigan is expected to get significant snowfall starting Wednesday afternoon and continuing into Thursday morning. The Lansing region is under a winter weather advisory, with 4 to 6 inches of snow expected by early Thursday. Some area school districts canceled afternoon activities on Wednesday.

In southeast Michigan and the Thumb area, the counties under a warning include Huron, Sanilac, St. Clair and Macomb. To the north, the counties under a warning include Alpena, Alcona, Ogemaw, Iosco, Gladwin and Arenac.