"The fire is growing with a moderate rate of spread and structures are threatened," Cal Fire said as it issued evacuation orders.
The Palisades and Eaton wildfires also continue burning in the Los Angeles area, leaving parts of Southern California with devastating fire damage.
Two new fires ignited in San Diego County on Tuesday, as firefighters continue fighting blazes further north in Los Angeles.
The Hughes Fire was first reported shortly after 10:30 a.m. along Lake Hughes Road, near Castaic Lake and the 5 Freeway, according to Cal Fire.
At least 27 people have died in the Eaton and Palisades fires, the Los Angeles County Medical Examiner said Thursday evening. Seventeen of the deaths are from the Eaton Fire in Altadena and 10 from the Palisades Fire, according to the medical examiner.
The Los Angeles County Sheriff's Department said in an update Thursday that 18 people remain missing after the Southern California wildfires. Overall, authorities received a total of 43 missing persons reports related to the Eaton and Palisades fires. Of those, 12 were located safe.
The Hughes Fire has spread over 5,054 acres after starting just before lunchtime in Los Angeles County's Castaic Lake area on Wednesday.
A second day of windy and dry conditions is in store for Southern California. Winds have picked up and are expected to continue through Tuesday morning, raising the risk of new wildfires sparking.
The Los Angeles haven’t spread in nearly a week, but the return of the Santa Ana winds to full strength could cause problems.
The Hughes fire, about 45 miles (72 km) north of Los Angeles, grew to more than 10,000 ... near San Diego and Oceanside. The Lilac fire was declared fully contained after burning 85 acres.
Several counties in Southern California faced "critical" fire risks this week, according to an AccuWeather forecast.
The Palisades Fire, which started on Jan. 7, has burned 23,713 acres and has destroyed 5,828 structures, including homes and businesses, according to an update from Cal Fire on Monday. At least 10 fire-related deaths have been reported in the Palisades Fire.