During the early window of Sunday's wild-card action, the Buffalo Bills defended their home turf at Highmark Stadium and sent the Denver Broncos packing with a 31–7 victory. Bo Nix and the Broncos got on the board early, taking a 7–0 lead before surrendering 31 straight points to the Josh Allen-led Bills offense.

Barkley took a handoff on second-and-6 from the Eagles' 24-yard line and found a hole to break through. A 74-yard touchdown was in Barkley's sights that would have made a lot of bettors happy for the anytime touchdown prop, even with the game in hand.